Analysis of STAG3 variants in Chinese non-obstructive azoospermia patients with germ cell maturation arrest
نویسندگان
چکیده
منابع مشابه
Association of PIWIL4 genetic variants with germ cell maturation arrest in infertile Spanish men
and allele frequencies in the patients and controls. Hardy–Weinberg equilibrium was tested by the χ 2 test. The significance level was established at P < 0.05. These statistical analyses were performed using the SPSS software version 12 (Lead Technologies, Chicago, USA). Pairwise linkage disequilibrium (LD) between SNPs, haplotype frequencies, and association analyses were performed with SNPass...
متن کاملHIWI2 rs508485 Polymorphism Is Associated with Non-obstructive Azoospermia in Iranian Patients
Background: The PIWI-interacting RNA (piRNA) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. HIWI genes are critical for piRNA biogenesis and function. Therefore, polymorphisms in HIWI genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. The aim of the present study was to i...
متن کاملPathogenic variants screening in five non-obstructive azoospermia-associated genes.
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility and a recent, genome-wide association study (GWAS) has identified four risk loci associated with NOA. However, a large portion of the heritability of NOA has not been well explained by GWAS. By hypothesizing that rare, low-frequency and common genetic variants might point toward a causal relation between candi...
متن کاملdeletion and testicular expression of daz (deleted in azoospermia) gene in patients with non-obstructive azoospermia
background: deletions of the daz (deleted in azoospermia) genes within the human y chromosome's azfc region are the most common cause of spermatogenesis failure. these deletions are usually assessed by analyses of genomic dna extracted from peripheral leukocytes. daz genes are expressed in male germ cells. in this prospective study, we investigated daz expression and deletion in 102 consecutiv...
متن کاملObstructive and Non-Obstructive Azoospermia
Azoospermia is defined as the complete absence of spermatozoa upon examination of the semen [including capillary tube centrifugation (CTC), strictly confirmed by the absence of spermatozoa issued in urine after ejaculation]. The presence of rare spermatozoa (<500.000/ml) in seminal fluid after centrifugation is called "cryptozoospermia". The complete absence of spermatozoa should be confirmed w...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-89559-9